Expression of Basic Fibroblast Growth Factor, Epidermal Growth Factor, and Their Receptors in Castrated and Testosterone Injected Rat Prostates





To examine the role of basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) and their receptors in androgeninduced cell growth in the rat prostate, we divided 36 male wistar rats into 3 groups, consisting of an uncastrated and nontestosterone injected (C) group, a castrated and non-testosterone injected (CA) group, and a castrated and testosterone injected (CT) group. Each group was divided again into 2 groups and sacrificed at 4 and 8 weeks after the treatment, respectively. Injection with testosterone propionate was done subcutaneously at 4 mg/kg for a week. The epithelial cells in CT prostates exhibited much higher proliferative cell nuclear antigen (PCNA) labelling index compared with those in C prostates, and the PCNA index of the stromal cells of both groups was similar. bFGF expression increased mainly in epithelial and stromal cells in CA group. bFGF mRNA level also increased in the 4 weeks CA group. FGFR expression increased in all kind of cells of CA group, in which total FGFR mRNA level was also high. EGF immunoreactivity was intense in the proliferating epithelial cells of CT group, and EGF mRNA was also detected in the same cells. Epithelial cells in CA group were positive for EGFR, but not in CT group. However, total EGFR mRNA level increased in CT group. Taken together, bFGF synthesized by epithelial and stromal cells may participate in fibrosis and angiogenesis in the castrated rat prostates. On the other hand, androgen may induce the prostatic epithelial cell proliferation through, at least in part, autocrine or paracrine mechanism of bFGF and EGF.


  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 30(1), 13-22, 1997-02-01


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