Adenosine 5'-Triphosphate Decreases the Permeability of a Mesothelial Cell Monolayer
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We have developed an <I>in vitro</I> assay system to evaluate permeability of a rat mesothelial cell monolayer and examined the direct effect of ATP. Rat peritoneal mesothelial cells formed a confluent monolayer on the membrane of a co-culture chamber. ATP at the concentration between 10<SUP>-6</SUP>-10<SUP>-4</SUP> M decreased the permeability of the monolayer to dextran in 4 hr. Since our assay system doesn't contain inflammatory cells, it is suggested that ATP directly modulates the cells and decreases the permeability.
- ACTA HISTOCHEMICA ET CYTOCHEMICA
ACTA HISTOCHEMICA ET CYTOCHEMICA 30(1), 37-39, 1997-02-01
JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY