Adenosine 5'-Triphosphate Decreases the Permeability of a Mesothelial Cell Monolayer

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Author(s)

    • TAKEDA Taichi
    • Department of Traumatology and Critical Care Medicine, Kyorin University School of Medicine
    • YUKIOKA Tetsuo
    • Department of Traumatology and Critical Care Medicine, Kyorin University School of Medicine
    • MATSUDA Hiroharu
    • Department of Traumatology and Critical Care Medicine, Kyorin University School of Medicine
    • SHIMAZAKI Syuji
    • Department of Traumatology and Critical Care Medicine, Kyorin University School of Medicine

Abstract

We have developed an <I>in vitro</I> assay system to evaluate permeability of a rat mesothelial cell monolayer and examined the direct effect of ATP. Rat peritoneal mesothelial cells formed a confluent monolayer on the membrane of a co-culture chamber. ATP at the concentration between 10<SUP>-6</SUP>-10<SUP>-4</SUP> M decreased the permeability of the monolayer to dextran in 4 hr. Since our assay system doesn't contain inflammatory cells, it is suggested that ATP directly modulates the cells and decreases the permeability.

Journal

  • ACTA HISTOCHEMICA ET CYTOCHEMICA

    ACTA HISTOCHEMICA ET CYTOCHEMICA 30(1), 37-39, 1997-02-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

References:  7

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008606010
  • NII NACSIS-CAT ID (NCID)
    AA00508022
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00445991
  • Data Source
    CJP  CJPref  J-STAGE 
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