Endothelin-Induced c-fos Expression in the Rat Forebrain

Access this Article

Search this Article

Author(s)

Abstract

The expression of c-<I>fos</I> was analyzed immunohistochemically after injection of endothelin isopeptide into cerebroventricle of the rat. The c-Fos immunoreactivity increased and reached the peak at 1 hr-1.5 hr after the administration of endothelin. Endothelin-1 and endothelin-2 specifically induced c-<I>fos</I>s expression in the neurons of paraventricular, supraoptic and periven-tricular nuclei and zona incerta. Endothelin-3 induced c-Fos in the organum vasculosum laminae terminalis in addition to those regions. In these areas, the number of c-Fos-positive neurons increased with a dose (Oto 100 pg of ET) dependent manner. We presume that they are the targeting neurons of central nervous endothelins (ETs).

Journal

  • ACTA HISTOCHEMICA ET CYTOCHEMICA

    ACTA HISTOCHEMICA ET CYTOCHEMICA 30(1), 51-56, 1997-02-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

References:  24

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008606054
  • NII NACSIS-CAT ID (NCID)
    AA00508022
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00445991
  • Data Source
    CJP  CJPref  J-STAGE 
Page Top