Expression of NCAM-H and S100 Protein in the Rostral Migratory Stream of the Adult Guinea Pig Forebrain

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Abstract

We demonstrated a double-labeled immunofluorescent cytochemistry under confocal laser scanning microscope, using antibodies against highly polysialylated isoform of neural cell adhesion molecule (NCAM-H), and Ca<sup>++</sup> binding astroglial marker in the brain, S100 protein (S100) in the rostral migratory stream (RMS) of the subependymal layer (SEL) of the adult guinea pig forebrain. In the adult olfactory system, NCAM-H is considered to be associated with the continuous generation and growth of granule cells. In the whole length of germinal SEL, varied populations of blast like, beaded, clustered NCAM-H positive elements were densely intermingled with typical astrocytic subpopulations of S100 protein. Some especialized phenotypes of S100 immunopositive ependymoglial tanycytes gave off their basal processes into NCAM-H immunopositive clusters in the rostral extention of subependymal zone (SEZ-re). Our results evinced the complex morphological multitude of neuro-glial (neuronal and neuroglial) coherence in the course of tangential migration of neuronal progenitors in the young adult guinea pig RMS.

Journal

  • ACTA HISTOCHEMICA ET CYTOCHEMICA

    ACTA HISTOCHEMICA ET CYTOCHEMICA 30(3), 315-318, 1997-06-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

References:  22

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008606989
  • NII NACSIS-CAT ID (NCID)
    AA00508022
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00445991
  • Data Source
    CJP  CJPref  J-STAGE 
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