Different Actions of Chinese Traditional Medicines against Adriamycin-induced Cytotoxicity
Prophylactic and curative effects of two tradi tional Chinese medicines, Rikkunshito (TJ-43) and Shigyakusan (TJ-35), against adriamycin (ADM) -induced cytotoxicity were studied in gastric epithelium and cardiac ventricular myocytes based on histochemical analysis of mitochondrial cytochrome oxidase (COX) activity. Oral administration of TJ-43 and TJ-35 prior to the injection of ADM preserved the COX activities both in gastric epithelium and cardiocytes to the normal levels. However, post-treatment with both drugs after ADM injection showed different enzyme activities between TJ-43-and TJ-35-treated groups. In both tissues, post-treatment of TJ-43 retained significant enzyme activity, whereas the enzyme activity of the TJ-35-treated groups was comparable or lower than that in ADM-injected controls without drug treatment. Although both TJ-43 and TJ-35 scavenge free radicals, no curative effect of TJ-35 against ADM-induced cytotoxicity was observed.
- Acta histochemica et cytochemica
Acta histochemica et cytochemica 30(5), 661-663, 1997-10-01
JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY