Different Actions of Chinese Traditional Medicines against Adriamycin-induced Cytotoxicity

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Author(s)

    • NODA Toru
    • Department of Anatomy, Faculty of Medicine, Kyoto Unviersity
    • YU Xiang Min
    • Department of Anatomy, Faculty of Medicine, Kyoto Unviersity
    • OGAWA Kazuo
    • Department of Anatomy, Faculty of Medicine, Kyoto Unviersity

Abstract

Prophylactic and curative effects of two tradi tional Chinese medicines, Rikkunshito (TJ-43) and Shigyakusan (TJ-35), against adriamycin (ADM) -induced cytotoxicity were studied in gastric epithelium and cardiac ventricular myocytes based on histochemical analysis of mitochondrial cytochrome oxidase (COX) activity. Oral administration of TJ-43 and TJ-35 prior to the injection of ADM preserved the COX activities both in gastric epithelium and cardiocytes to the normal levels. However, post-treatment with both drugs after ADM injection showed different enzyme activities between TJ-43-and TJ-35-treated groups. In both tissues, post-treatment of TJ-43 retained significant enzyme activity, whereas the enzyme activity of the TJ-35-treated groups was comparable or lower than that in ADM-injected controls without drug treatment. Although both TJ-43 and TJ-35 scavenge free radicals, no curative effect of TJ-35 against ADM-induced cytotoxicity was observed.

Journal

  • ACTA HISTOCHEMICA ET CYTOCHEMICA

    ACTA HISTOCHEMICA ET CYTOCHEMICA 30(5), 661-663, 1997-10-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

References:  6

Codes

  • NII Article ID (NAID)
    10008608196
  • NII NACSIS-CAT ID (NCID)
    AA00508022
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00445991
  • Data Source
    CJP  J-STAGE 
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