Age-Related Changes in the Immunohistochemical Localization of Inducible Nitric Oxide Synthase (iNOS) and Nuclear Factor-kappa B (NF-.KAPPA.B) in the Mouse Cochlea.
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- Kimura Masaru
- Department of Anatomy, Aichi Medical University
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- Wu Men-dar
- Department of Otorhinolaryngology, Aichi Medical University
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- Inafuku Shigeru
- Department of Otorhinolaryngology, Aichi Medical University
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- Ishigami Hiromichi
- Department of Otorhinolaryngology, Aichi Medical University
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Localization of iNOS and NF-κB in the cochlear tissues of ddy-strain mice was studied immunohistochemically with reference to ageing. Severe structural disorders with a decrease in the number of cells were found, especially in the organ of Corti and in the spiral ganglion of older mice. Throughout all age-spans studied, iNOS-like immunoreactivity was found in the cells of Hensen, Claudius and the outer spiral sulcus epithelium, and it increased dramatically with age. A very small number of cells in the stroma of the spiral ligament and spiral limbus of younger mice up to 12 months of age showed weak iNOS immunoreactivity, while the spiral ganglion cells of the younger mice were almost negative. In mice after 18 months of age, however, strong iNOS immunoreactive cells remarkably increased in the spiral ligament and spiral limbus. Moreover, spiral ganglion neurons that survived from age-related cell death also showed strong reactivity. The immunohistochemical localization of NF-κB and its change with age were nearly the same as those of iNOS. The possible roles of iNOS and NF-κB in the changes of mouse cochlear tissues with advancing age were discussed.
収録刊行物
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- Acta Histochemica et Cytochemica
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Acta Histochemica et Cytochemica 31 (6), 493-500, 1998
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詳細情報 詳細情報について
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- CRID
- 1390282679840131968
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- NII論文ID
- 10008609806
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- NII書誌ID
- AA00508022
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- COI
- 1:CAS:528:DyaK1MXhslehs7k%3D
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- ISSN
- 13475800
- 00445991
- http://id.crossref.org/issn/00445991
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可