ｓｍ胃癌におけるリンパ行性転移危険因子の研究　　病理組織学的・免疫組織学的検討

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  • Relationship between lymph node metastasis risk and cell adhesion molecules in submucosal cancer of the stomach-An immunohistological study.
  • AN IMMUNOHISTOLOGICAL STUDY
  • 病理組織学的・免疫組織学的検討

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Using immunohistochemistry, we studied the expression of E-cadherin (E-cad), a calcium-dependent cell-cell adhesion molecule, and α, β-catenin (α, β-cat), an E-cad-associated cytoplasmic protein that regulates E-cad function in early gastric cancer with submucosal invasion (submucosal gastric cancer). We also studied the correlation between the expression of E-cad, α, β-cat and clinicopathological features.<br> Subjects were 39 patients with submucosal gastric cancer -33 men and 6 women- undergoing surgical resection, including 10 cases of lymph node metastasis.<br> Submucosal gastric cancer with lymph node metastasis showed expansive submucosal infiltration with a massive volume of cancer cell invasion. Many cases of lymph node metastasis showed a reduction and absence of E-cad, α-cat, and β-cat, and particularly E-cad. This was evident in lymph node metastasis and biopsy specimens, similar to the expression seen in surgical specimens. The expression of E-cad either decreased or disappeared in 80% of the metastasized cases (8/10) and the loss of expression was significantly decreased (p<0.05).<br> These results suggest that the correlation between the expression of adhesion molecules (E-cad, α, β-cat) and histopathological features may be a factor that indicates early gastric cancer likely to metastasize to lymph nodes preoperatively based on biopsy sections.

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