Ｇａｓｔｒｏｉｎｔｅｓｔｉｎａｌ　ｓｔｒｏｍａｌ　ｔｕｍｏｒ　（ＧＩＳＴ）の臨床病理学的，免疫組織化学的検討

DOI Web Site 被引用文献9件 参考文献16件

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  • Clinicopathologic and immunohistochemical study of gastrointestinal stromal tumors (GIST).

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We clinicopathologically and immunohistochemically analyzed 30 patients with gastrointestinal stromal tumors (GIST) resected at our department to determine the clinical significance of GIST. Malignant potential was evaluated by tumor size and histopathological findings. Immunohistochemical classification as smooth muscle, neural, combined smooth muscle and neural, and noncommittal evaluated using α-SMA, S-100, CD34, and c-kits. Four patients suffering metastasis or recurrence had large malignant GISTs growing to the extralumen with ulcer formation and central bleeding. Three with GISTs originating in the small intestine died of peritoneal or liver metastasis. Multivariate analysis indicated that the significant prognostic factor was tumor size not immunohistochemical classification, is why the difficulty in diagnosing large GISTs causes poor prognosis. Potential consequences using macroscopic findings, including tumor size, must thus be used in addition to histopathological malignant potential rather than immunohistochemical classification.

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