書誌事項
- タイトル別名
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- Clinicopathological and immunohistochemical study on gastrointestinal stromal tumor (GIST).
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抄録
Immunohistochemical and clinicopathological features of 11 cases of gastrointestinal stromal tumors (GIST) operated on at the department during the recent 7 years were studied.<br> Factors studied were preoperative diagnosis, immunohistochemical features, malignancy and therapeuic methods. Eight GISTs occurred in the stomach, one in the duodenum and two in the small intestine. Nine patients were symptomatic at the time of admission. All tumors including one with liver metastasis were resectable. Emergency operations were performed in three cases. Recurrence occurred in three cases after the operation.<br> By using indirect immunoperoxidase staining for Cajal cell markers (c-kit and CD34), smooth muscle marker (α-smooth muscle actin (SMA)) and Schwann cell marker (S-100 protein), these cases were classified into two groups, an uncommitted type (n=8) and a smooth muscle type (n=3).<br> C-kit protein (11/11, 100%) and CD34 (9/11, 81%) were commonly and diffusely expressed in these cases. We thought that p53 and Ki-67 were useful factors for the prediction on malignancy and prognosis.<br> We could not clarify the relation between the malignant potential and biological characteristics of GISTs in these limited cases, but further investigations on the immunological and clinicopathological aspects of each GIST will contribute to establish the treatment of this disease.
収録刊行物
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- 日本臨床外科学会雑誌
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日本臨床外科学会雑誌 63 (4), 834-838, 2002
日本臨床外科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204844999680
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- NII論文ID
- 130003602940
- 10008618693
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- NII書誌ID
- AA11189709
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- ISSN
- 18825133
- 13452843
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可