The Control Leprous Peripheral Neuropathy and Chemotherapy.

• Gidoh Masaichi

  Leprosy Research Center, National institute of Infectious Diseases

Bibliographic Information

Other Title

• 化学療法からみたハンセン病末梢神経障害抑制

Abstract

Clarithromycin(CAM), Roxithromycin(RXM), Minocycline(MINO) and Fosfomycin(FOM) has anti-inflammatory action and immunomodulatory activity, while the anti-mycobacterium leprae activity is shown. CAM and RXM suppress the rat carrageenin edema, and MINO suppresses the rat adjvant arthritis. There is the immunosuppression on adrenocorticosteroid while the inflammatory cytokine is suppressed. CAM, MINO, FOM suppresses the inflammatory cytokine, while it has the immunomodulatory activity. Fusidic acid(FA) suppresses the inflammatory cytokine with the action of being similar to cyclosporin A, and it has the immunomodulatory activity. New macrolides derivatives, CAM and RXM showed the inflammatory regulation, and MINO showed the anti-inflammatory activity with FA. The combination chemotherapy can be enforced, while peripheral neuropathy is prevented by the control of the leprosy reaction.

Journal

• JAPANESE JOURNAL OF LEPROSY

  JAPANESE JOURNAL OF LEPROSY 68 (2), 83-86, 1999

  Japanese Leprosy Association

Keywords

• Mulidrug therapy(MDT)
• Anti-inflammtory effect
• Immunomodulator
• Leprosy Reaction

Details

• CRID: 1390282681298330880
• NII Article ID: 10008625664
• NII Book ID: AN10559906
• DOI: 10.5025/hansen.68.83
• ISSN: 1884314X
• ISSN: 13423681
• PubMed: 10481449
• Web Site: https://search.jamas.or.jp/link/ui/2000160362
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed