日本における創薬 : 過去と現状から将来への課題 [in Japanese] Innovative drug discovery in Japan : past, present and future problems [in Japanese]
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Although many new chemical entities have been put into therapeutic drug market in Japan, innovative drug discovery from Japanese pharmaceutical industries is poor.<BR> Author divided innovative drug discovery sciences into two phases: The first phase consist of discovery of seed compound and development of lead compound from seed compound. The second phase consist of development of therapeutic drug from lead compound. Strategic drug metabolism studies and toxicological studies are indispensable for rescue of toxicologically and pharmacokinetically difficult compounds. The author emphasize the importance of development of sciences for the second phase for innovative drug discovery. The author also pointed out the necessity of colaborations among universities, industries and regulatory agent for the promotion of innovative drug discovery.
- Folia Pharmacologica Japonica
Folia Pharmacologica Japonica 106, 20-22, 1995-09-01
The Japanese Pharmacological Society