気管平滑筋細胞のCa依存性Clチャネルとその活性化の情報伝達  [in Japanese] Signal transduction for activation of Ca-dependent Cl channel in tracheal smooth muscle cells of the guinea-pig  [in Japanese]

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Author(s)

    • 今泉 祐治 IMAIZUMI Yuji
    • 名古屋市立大学薬学部薬品作用学教室 Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
    • 邊見 智 HENMI Satoshi
    • 名古屋市立大学薬学部薬品作用学教室 Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
    • 渡辺 稔 WATANABE Minoru
    • 名古屋市立大学薬学部薬品作用学教室 Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University

Abstract

TMEM16A is a major component of Ca<sup>2+</sup>-activated Cl<sup>−</sup> channel (CaCC) conductance in murine portal vein smooth muscle cells (mPVSMCs). Here, the regulation of CaCC activity by the actin cytoskeleton was examined in mPVSMCs. Actin disruption by cytochalasin D did not affect the current density, but increased the deactivation time constant in mPVSMCs. The elongated deactivation was recovered by jasplakinolide. When murine TMEM16A was transfected into HEK293 cells that have a poorly developed actin cytoskeleton, electrophysiological properties of CaCC currents were not changed by cytochalasin D. In conclusion, the CaCC activity in mPVSMCs is modified by the interaction of TMEM16A with abundant actin cytoskeleton.

Journal

  • Journal of Pharmacological Sciences

    Journal of Pharmacological Sciences 106, 107-111, 1995-09-01

    The Japanese Pharmacological Society

Codes

  • NII Article ID (NAID)
    10008631338
  • NII NACSIS-CAT ID (NCID)
    AN00198335
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    00155691
  • NDL Article ID
    025463221
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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