ボピンドロール投与による高血圧自然発症ラット(SHR)の心筋α_1-及びβ-受容体の性状変化に関する研究 Effects of Chronic Administration of Bopindolol on the ^3H-Prazosin and ^3H-CGP12177 binding to α_1- and β-Adrenoceptors in the Heart of Spontaneously Hypertensive Rats(SHR)

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We investigated the effects of chronic administration of bopindolol in the heart of spontaneously hypertensive rats (SHR) The values of Kd and Bmax of α<SUB>1</SUB> and β-adrenoceptors in the heart of SHR were calculated by Scatchard analysis used <SUP>3</SUP>H-prazosin and <SUP>3</SUP>H-CGP 12177 binding. In addition, their blood pressure was also determined and these effects of bopindolol were compared with those of other β-blockers. SHR were given bopindolol (1 mg/kg and 3 mg/kg), atenolol (50 mg/kg), propranolol (60 mg/kg) in drinking water during 12 weeks. The systolic blood pressure of SHR was lowered by chronic administration of bopindolol, dose-dependently observed. The chronic administration of bopindolol (3 mg/kg) to SHRs increased the Kd and Bmax values of the a lx-adrenoceptors (high affinity binding sites for <SUP>3</SUP>H-prazosin). On the other hand, the administration of bopindolol (1 mg/kg and 3 mg/kg) decreased the Bmax values of the β-adrenoceptor. These findings suggest that chronic administration of bopindolol had a beneficial effect on the blood pressure and had a dose-dependent effect on the α<SUB>1</SUB>- and β-adrenoceptors in the heart. These effects of bopindolol maybe involved in the inhibition of the development of hypertension.

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  • 日本薬理学雑誌

    日本薬理学雑誌 106, 177-181, 1995-09-01

    公益社団法人 日本薬理学会

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