新規合成アズレン-1-カルボキサミジン誘導体HNS-32の心血管におよぼす作用  [in Japanese] Cardiovascular Effects of Novel Azulene-1-Carboxamidine Derivative, HNS-32  [in Japanese]

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Abstract

A novel azulene-1-carboxamidine delivative (HNS-32) was synthesized and its cardiovascular effects were assessed using well-established isolated, blood-perfused, canine sinoatrial node, papillary muscle and atrioventricular node preparations. The yields of HNS-32 was about 44 % of the amount expected from the chemical equation. The found, chemical structure, molecular weight and color of HNS-32 were C<SUB>24</SUB>H<SUB>30</SUB>N<SUB>3</SUB>, N<SUP>1</SUP>-dimethyl-N<SUP>2</SUP>-(2-picolino) azulene-l-carboxamidine, 360.242 and dark blue, respectively. HNS-32 suppressed the sinus nodal automaticity and contractile force, while increased the coronary blood flow and AH and HV intervals (n=5). The drug shortened the repolarization phase of monophasic action potentials of right ventricle (n=4). The vasodilator effect was 3-10 times more potent than each cardiac effect. The pharmacological properties resemble those of calcium channel blocking drugs with modest sodium channel inhibition and potassium channel opening. HNS-32 may become a new drug with unique chemical structure that affects cardiovascular system.

Journal

  • Folia Pharmacologica Japonica

    Folia Pharmacologica Japonica 106, 192-196, 1995-09-01

    The Japanese Pharmacological Society

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