血栓形成における5-hydroxytryptamine (5-HT)の役割と51HT_<2A>拮抗薬の作用  [in Japanese] Role of 5-hydroxytryptamine (5-HT) in thrombus formation and effects of 5-HT_<2A> antagonists  [in Japanese]

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Abstract

We investigated the role of 5-HT in thrombus formation and the effects of 5-HT<SUB>2A</SUB> antagonists in rabbit platelets and isolated aortic vessels. 1) Supernatant of collagen-aggregated platelets induced further aggregation volume-dependently. The supernatant-induced aggregation was inhibited by either 5-HT<SUB>2A</SUB> antagonists or ADP scaverger. 2) The supernatant induced contraction of the aortic vessels volume-dependently. The supernatant-induced contraction was inhibited by 5-HT<SUB>2A</SUB> antagonists but not by ADP scaverger. 3) The sensitivity of aortic vessels to the supernatant and to the inhibitory effects of 5-HT<SUB>2A</SUB> antagonists was 20 to 175 times higher than that of platelets.<BR> These findings suggest that 5-HT released from the platelets by stimulation of collagen fibrils induces furter aggregation and contraction of vascular vessels via 5-HT<SUB>2A</SUB> receptors, accelerating arterial thrombus formation. These 5-HT<SUB>2A</SUB> antagonists may improve effectively the thrombus formation by inhibiting the platelet aggregation and the vascular contraction.

Journal

  • Folia Pharmacologica Japonica

    Folia Pharmacologica Japonica 106, 197-201, 1995-09-01

    The Japanese Pharmacological Society

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