拘束ストレスによるラット脳内β-アドレナリン受容体の変動と高血圧 [in Japanese] IMMOBILIZATION STRESS-INDUCED HYPERTENSION AND DOWN-REGULATION OF CENTRAL β-ADRENOCEPTORS IN RATS [in Japanese]
Access this Article
Search this Article
Effects of chronic treatment with propranolol or atenolol on stress-induced changes in blood pressure and cerebral β-adrenoceptors were examined in rats. Immobilization stress (2 h daily for 2 weeks) induced a moderate elevation of blood pressure and downregulation of cerebral β-adrenoceptors. Chronic administration of propranolol (5 mg•kg<SUP>-1</SUP>) or atenolol (5 mg•kg<SUP>-1</SUP>) inhibited stress-induced hypertension. Propranolol and atenolol increased the density of cerebral β-adrenoceptors and inhibited the downregulation induced by stress. These results suggest that the antihypertensive action of propranolol and atenolol may be partly associated with the inhibition of stress-activated central β-adrenoceptor transmission.
- Folia Pharmacologica Japonica
Folia Pharmacologica Japonica 106, 227-230, 1995-09-01
The Japanese Pharmacological Society