Ｉｆｅｎｐｒｏｄｉｌ　ｔａｒｔｒａｔｅのＩｎ　ｖｉｔｒｏおよびＥｘ　ｖｉｖｏにおけるウサギ血小板凝集抑制作用

• 入野 理

  グレラン製薬(株)研究開発本部

• 斉藤 清

  グレラン製薬(株)研究開発本部

• 林 俊宏

  グレラン製薬(株)研究開発本部

• 大久保 一三

  グレラン製薬(株)研究開発本部

書誌事項

タイトル別名

• Inhibitory mechanism of ifenprodil tartrate on rabbit platelet aggregation.
• Ifenprodil tartrate ノ In vitro オヨビ Ex v

抄録

The effects of dl-erythro-4-benzyl-α-(4-hydroxyphenyl)-β-methyl-l-piperidine-ethanol tartrate (ifenprodil tartrate) on rabbit platelet aggregation in vitro and ex vivo were studied. Ifenprodil tartrate inhibited platelet aggregation in vitro induced by ADP, collagen and epinephrine. It also inhibited 5-hydroxytryptamine (5-HT) uptake into platelets and 5-HT release from platelets. Since these inhibitory effects of ifenprodil tartrate on the functions of rabbit platelets were similar to the effects of imipramine, the effects of ifenprodil tartrate may be due to the stabilizing action of ifenprodil tartrate on the platelet membrane. The platelet aggregation by ADP was significantly inhibited in rabbits after oral administration of ifenprodil tartrate, the maximal plasma level of ifenprodil being reached at 20 ng/ml ex vivo, while the maximal level was only 1/40 of the minimal concentration of ifenprodil tartrate necessary to inhibit platelet aggregation in vitro. These results indicate that factors other than ifenprodil tartrate acting directly on the platelets (e.g., PGI₂ which is an endogenous inhibitor of platelet aggregation) are involved in inducing the inhibitory effects of ifenprodil tartrate on platelet aggregation ex vivo. The effects of ifenprodil tartrate on both PGI2₂ release from the aorta and the inhibitory effects of PGI₂ on platelet aggregation in vitro were investigated: PGI₂ was found to intensify the inhibitory effects of ifenprodil tartrate on platelet aggregation in vitro, but there was little effect, if any, on PGI₂ release. Therefore, it is considered that the ex vivo effects of ifenprodil tartrate might be due to its interaction with endogenous PGI₂ in the blood.

収録刊行物

• 日本薬理学雑誌

  日本薬理学雑誌 85 (5), 379-385, 1985

  公益社団法人 日本薬理学会

キーワード

• Pharmacology

詳細情報

• CRID: 1390001204272436352
• NII論文ID: 130000761807
• NII論文ID: 10008633540
• NII書誌ID: AN00198335
• DOI: 10.1254/fpj.85.379
• COI: 1:CAS:528:DyaL2MXktlaisrc%3D
• ISSN: 13478397
• ISSN: 00155691
• NDL書誌ID: 3037924
• PubMed: 3896987
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3037924
• Web Site: https://search.jamas.or.jp/link/ui/1985164538
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可