心臓手術後の抗凝固療法開始早期における正常プロトロンビン量（ＣＡ‐１法）の変化

• 工藤 龍彦

  東京医科大学八王子医療センター, 心臓血管外科

• 田中 朝志

  東京医科大学八王子医療センター, 臨床病理学

• 山田 大介

  明治薬科大学, 生体分子学教室

• 森田 隆司

  明治薬科大学, 生体分子学教室

書誌事項

タイトル別名

• Changes of Normal Prothrombin Level(CA-1 Method) from the Start of Anticoagulant Therapy after Heart Surgery.

抄録

Normal prothrombin, i.e., fully γ-carboxylated prothrombin in plasma is now measurable by a chromogenic assay using carinactivase-1 (CA-1) isolated from the Echis carinatus leucogaster venom. This enzyme has been shown to solely activate fully γ-carboxylated prothrombin but not so-called PIVKA-II lacking one or more γ-carboxyglutamic acids in the prothrombin molecule. The plasma level of normal prothrombin was determined by the chromogenic assay utilizing this enzyme in 10 patients who had undergone heart surgery and had been treated with warfarin postoperatively. Plasma samples were collected from day 4 to day 20 after surgery and the data were compared with the values of thrombotest (TT) and the prothrombin time-international normalized ratio (PT-INR).<br>The level of normal prothrombin decreased in all patients after initiation of the warfarin therapy, and the extent of the decrease was found to correlate with TT positively, but with PT-INR negatively. Since the CA-1 method can be conducted very rapidly and requires only a small amount of plasma, this method is expected to be clinically utilized for monitoring the warfarin therapy after appropriate improvement in the assay system.

収録刊行物

• 日本血栓止血学会誌

  日本血栓止血学会誌 10 (4), 260-266, 1999

  一般社団法人 日本血栓止血学会

キーワード

• CA-1 method
• normal prothrombin
• anticoagulant therapy
• thrombotest
• PT-INR

詳細情報

• CRID: 1390001204443881856
• NII論文ID: 130004262226
• NII論文ID: 10008633757
• NII書誌ID: AN10353762
• DOI: 10.2491/jjsth.10.260
• ISSN: 18808808
• ISSN: 09157441
• Web Site: https://search.jamas.or.jp/link/ui/2000072582
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可