振動障害患者の凝固線溶能に関する研究

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  • Studies on the Markers of Activation of Coagulation and Fibrinolysis in the Patients with Occupational Vibration Syndrome

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The peripheral circulatory disturbances caused by long term use of vibratory instruments, characterized typically by the development of Raynaud's phenomenon on the fingers have been recognized as occupational vibration syndrome (VS).<br>In order to elucidate the possible mechanisms of these peripheral disturbances, we studied the molecular markers of coagulation and fibrinolysis in patients with VS.<br>Seventy one patients and 111 healthy persons as a control were used in this study.<br>The following results were obtained;<br>1. The Thrombin-antithrombin complex (TAT)/plasmin α2 plasmin inhibitor complex (PIC) ratio of patients with VS was significantly higher than that of the control.<br>2. The TAT/PIC ratio of the Raynaud's phenomenon positive group was higher than that of the Raynaud's phenomenon negative group in the patients with VS.<br>3. The TAT/PIC ratio increased parallel to the severity of Raynaud's phenomenon.<br>4. Other parameters such as fibrinogen, TAT, fibrinopeptide A (FPA), fibrinopeptide Bβ15-42 (FPB) and PIC of the Raynaud's phenomenon positive group were also higher than those of the Raynaud's phenomenon negative one.<br>These results suggest that both the activity of coagulation and fibrinolysis were elevated in the patients with VS.<br>Moreover, the activation markers of coagulation such as TAT were apparently more dominant than the activation markers of fibrinolysis such as PIC.<br>Thus from these findings it is deduced that hypercoagulability may play an important role in the development of peripheral circulatory disturbances in patients with VS.

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