Novel Mutations of the CYP2A6 Gene in a Thai Population with Lowered Capacity of Coumarin 7-Hydroxylation

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  • KIYOTANI Kazuma
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
  • YAMAZAKI Hiroshi
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
  • FUJIEDA Masaki
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
  • DAIGO Satoshi
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
  • SATARUG Soisungwan
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
  • UJJIN Pailin
    Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University
  • KAMATAKI Tetsuya
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University

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  • Novel mutations of the CYP2A6 gene in a Thai population with capacity of coumarin 7-hydroxylation

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Abstract

  We explored genetic polymorphisms in a Thai population which exhibited a low capacity to metabolize coumarin. The following two silent single nucleotide polymorphisms (SNPs) were found:<br>   1) SNP, 020228Kiyotani001; GENE NAME, CYP2A6; ACCESSION NUMBER, NT_011139; LENGTH, 25 base; 5′-AAACTACCTGCAG/TCTGAACACAGAG-3′.<br>   2) SNP, 020228Kiyotani002; GENE NAME, CYP2A6; ACCESSION NUMBER, NT_011139; LENGTH, 25 base; 5′-AATCCCCAGCAC/TTTCCTGAATGAG-3′.<br>   These two mutations (G144A and C1245T), which were located in exon 1 and exon 8 of the CYP2A6 gene, were found in two subjects among nine poor metabolizers for coumarin.<br>

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