A Major Genotype in UDP-glucuronosyltransferase 2B15

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Author(s)

    • TOIDE Kenji
    • Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
    • UMEDA Shin-ichiro
    • Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
    • YAMAZAKI Hiroshi
    • Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
    • TAKAHASHI Yoshiki
    • Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
    • KAMATAKI Tetsuya
    • Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University

Abstract

  A novel single nucleotide polymorphism (SNP) was found in exon 6 of the UDP-glucuronosyltransferase (UGT) 2B15 gene from healthy Japanese populations.<br>   The SNP was as follows: SNP, 020228Toide001; GENE NAME, <i>UGT2B15</i>; ACCESSION NUMBER, U08854, AF180322, and NM_001078; LENGTH, 25 base; 5′-AGCTTGCCAAAA<u><b>C/A</b></u>AGGAAAGAAGAA-3′.<br>   This SNP was expected to cause a change of an amino acid residue at the position 523 (Thr to Lys) located in a putative co-factor binding region. The allele frequency of this SNP was 79% in Japanese, suggesting this polymorphism to be a major genotype in Japanese people.<br>

Journal

  • Drug Metabolism and Pharmacokinetics

    Drug Metabolism and Pharmacokinetics 17(2), 164-166, 2002-05-31

    The Japanese Society for the Study of Xenobiotics

References:  8

Codes

  • NII Article ID (NAID)
    10008666269
  • NII NACSIS-CAT ID (NCID)
    AA1162652X
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    09161139
  • Data Source
    CJP  J-STAGE 
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