Clinicopathological Study of Salivary Duct Carcinoma
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- Shimizu Akira
- Department of Otolaryngology, Tokyo Medical University
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- Yamane Masaaki
- Department of Otolaryngology, Tokyo Metropolitan Police Hospital
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- Ito Hiroyuki
- Department of Otolaryngology, Tokyo Medical University
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- Araki Susumu
- Department of Otolaryngology, Tokyo Medical University
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- Yoshida Tomoyuki
- Department of Otolaryngology, Tokyo Medical University
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- SUZUKI MAMORU
- Department of Otolaryngology, Tokyo Medical University
Bibliographic Information
- Other Title
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- Salivary Duct Carcinomaの臨床•免疫組織学的検討
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Abstract
Salivary duct carcinoma (SDC) was first described by Kleinsesser in 1968 and was classified as an independent entity by the 1991 Revised World Health Organization. It is a rare but highly malignant tumor. We reviewed pathology in 49 cases of salivary adenocarcinoma, and diagnosed 6 cases as SDC. All had a rapidly enlarged mass in the parotid gland. All were men, and 4 involved facial palsy and metastasis to cervical lymph nodes. Fine needle aspiration biopsy was conducted in 3 cases, but none was diagnosed as SDC. Two had chemotherapy, but showed no effect. All underwent surgery, but only 1 survived more than 4 years. Immunohistochemically, none showed s-100 protein. Four showed PCNA and p53 protein. Highly positive cells of PCNA and p53 were found around comedo necrosis.
Journal
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- Nippon Jibiinkoka Gakkai Kaiho
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Nippon Jibiinkoka Gakkai Kaiho 105 (6), 727-731, 2002
Japanese Society of Otorhinolaryngology-Head and neck surgery
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Details 詳細情報について
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- CRID
- 1390001205009462528
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- NII Article ID
- 10008674914
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- NII Book ID
- AN00191551
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- COI
- 1:STN:280:DC%2BD38zptVWhtA%3D%3D
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- ISSN
- 18830854
- 00306622
- http://id.crossref.org/issn/00306622
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- PubMed
- 12138700
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed
