Effects of the membrane pressure of reverse osmosis device against the concentration of endotoxin in the reverse osmosis water.

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  • 逆浸透装置膜圧の処理水エンドトキシン濃度に及ぼす影響

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Abstract

According to the guidelines for water purification of dialysate published in the Journal of the Japanese Society for Dialysis Therapy, we started to sterilize both the membrane of the reverse osmosis device and dialysate supplying line using formaldehyde. After sterilization, endotoxin concentrations were significantly reduced from 117, 122, 98EU/L to 24, 20, 36EU/L in the reverse osmosis tank, central supply system, and the end of the console in system A, respectively. However, endotoxin concentrations of the reverse osmosis tank were unchanged in system B. When comparing these 2 systems, we found that the membrane pressure of the reverse osmosis device in system B was approximately 2 times higher than that in system A. When the membrane pressure of system B was reduced to the same level as system A, the endotoxin concentration in the reverse osmosis tank was significantly reduced. From these findings, we examined the relationship between the membrane pressure of the reverse osmosis device and the endotoxin concentration. The endotoxin concentration at a low membrane pressure (0.86 MPa) was significantly lower than that at a high membrane pressure (1.67 MPa). When we measured the endotoxin concentration at various membrane pressure levels, the endotoxin concentration had a significant positive relationship with the level of membrane pressure (r=0.65, p<0.05). Therefore, we suggest that the endotoxin concentration might decline with a reduction of membrane pressure in the reverse osmosis device. This might be a new method of reducing endotoxin concentration.

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