Altered Prostaglandin Metabolism Induced by Angiotensin-Converting Enzyme Inhibitors in Broncho-Alveolar Lavage Fluid of the Guinea Pig

Access this Article

Search this Article

Author(s)

Abstract

The aim of this study was to investigate if prostaglandin (PG) metabolism is altered by angiotensin-converting enzyme (ACE) inhibitors as determined in the broncho-alveolar lavage fluid (BALF) of the guinea pig. Enalapril or imidapril was orally administered once a day for 2 weeks to Hartley male guinea pigs. Twenty-four hours after the last treatment, BALF was collected and the concentrations of PGI<SUB>2</SUB>, thromboxane A<SUB>2</SUB> (TXA<SUB>2</SUB>) and PGE<SUB>2</SUB> were measured by enzyme immunoassay. Enalapril significantly (P<0.05) increased the TXA<SUB>2</SUB> content, which was inhibited by indomethacin treatment and significantly (P<0.05) decreased the PGI<SUB>2</SUB> content. Imidapril, however, did not affect TXA<SUB>2</SUB> or PGI<SUB>2 </SUB> generation. These findings suggest that altered PG metabolism may be associated with coughing as a side effect of enalapril.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 72(1), 17-21, 1996-09-01

    The Japanese Pharmacological Society

References:  24

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008675536
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • Data Source
    CJP  CJPref  J-STAGE 
Page Top