Ca^2+ Depletion Facilitates Taurine Release in Cultured Rat Astrocytes

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Author(s)

Abstract

Removal of external Ca<SUP>2+</SUP> facilitated endogenous taurine release in cultured rat astrocyies. The stimulated release was not affected by furosemide, sucrose, tetrodotoxin and 3, 4-dichlorobenzamil, but partially inhibited by nifedipine. Omission of external Na+ increased basal taurine release, and the effects of Na<SUP>+</SUP> removal and Ca<SUP>2+</SUP> depletion on the release were additive. The Na<SUP>+</SUP>-free condition did not affect Ca<SUP>2+</SUP> paradox-induced cell death in astrocyies. These findings suggest that Ca<SUP>2+</SUP> depletion facilitates taurine release in a mechanism independent of volume and the Na+ gradient and that the release is not involved in Ca<SUP>2+</SUP> paradox-induced delayed cell toxicity in astrocytes.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 72(1), 75-78, 1996-09-01

    The Japanese Pharmacological Society

References:  12

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008675744
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • Data Source
    CJP  CJPref  J-STAGE 
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