Ca2+ Depletion Facilitates Taurine Release in Cultured Rat Astrocytes.

• Takuma Kazuhiro

  <I>Department of Pharmacology</I>

• Matsuda Toshio

  <I>Department of Pharmacology</I>

• Kishida Yoko

  <I>Department of Pharmacology</I>

• Asano Shoichi

  <I>Department of Pharmacology</I>

• Azuma Junichi

  <I>Department of Clinical Evaluation of Medicine and Therapeutics, Faculty of Pharmaceutical Sciences, Osaka University</I>

• Baba Akemichi

  <I>Department of Pharmacology</I>

抄録

Removal of external Ca²⁺ facilitated endogenous taurine release in cultured rat astrocyies. The stimulated release was not affected by furosemide, sucrose, tetrodotoxin and 3, 4-dichlorobenzamil, but partially inhibited by nifedipine. Omission of external Na+ increased basal taurine release, and the effects of Na⁺ removal and Ca²⁺ depletion on the release were additive. The Na⁺-free condition did not affect Ca²⁺ paradox-induced cell death in astrocyies. These findings suggest that Ca²⁺ depletion facilitates taurine release in a mechanism independent of volume and the Na+ gradient and that the release is not involved in Ca²⁺ paradox-induced delayed cell toxicity in astrocytes.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 72 (1), 75-78, 1996

  公益社団法人 日本薬理学会

キーワード

• Taurine release
• Ca<SUP>2+</SUP> paradox
• Astrocyte

詳細情報

• CRID: 1390282679263114368
• NII論文ID: 10008675744
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.72.75
• COI: 1:CAS:528:DyaK28Xlsl2nsrk%3D
• ISSN: 13473506
• ISSN: 00215198
• PubMed: 8902603
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819339496?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819339496?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1997042769
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可