Effects of Toborinone (OPC-18790), a New Positive Inotropic Agent, on Action Potential in Guinea Pig Sinoatrial Node: Compared with Milrinone and E-403

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Author(s)

    • ORITO Kensuke
    • 2nd Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.
    • TAKASE Hiromichi
    • 2nd Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.
    • FUJIKI Hiroyuki
    • 2nd Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.
    • MORI Toyoki
    • 2nd Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.

Abstract

The effects of toborinone ([(±)-6-[3-(3, 4-dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinone], OPC-18790), milrinone and E-4031 (1-(2-(6-methyl-2-pyridil)-1-ethyl)-4-(4-methanesulfonyl-amino-1-benzoyl)piperidine dihydrochloride) on membrane potential were examined in isolated guinea pig sinoatrial node preparations. Toborinone, a new positive inotropic agent, prolonged cycle length (CL), depolarized maximum diastolic potential (MDP) and decreased maximum upstroke velocity (V<SUB>max</SUB>) and action potential amplitude (APA). On the other hand, milrinone, a peak III phosphodiesterase (PDE III) inhibitor, increased V<SUB>max</SUB> and APA and shortened CL and action potential duration. E-4031, an I<SUB>K</SUB> blocker, prolonged CL, depolarized MDP and decreased V<SUB>max</SUB> and APA. These results suggest that toborinone modulates the action potential like an I<SUB>K</SUB> blocker rather than a PDE III inhibitor in a sinoatrial node.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 72(1), 79-82, 1996-09-01

    The Japanese Pharmacological Society

References:  12

Codes

  • NII Article ID (NAID)
    10008675757
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • Data Source
    CJP  J-STAGE 
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