Characterization of Dextran Sulfate-Induced Guinea Pig Tracheal Plasma Extravasation.
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- Morimoto Hiroshi
- <I>Department of Pharmacology</I>
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- Yamashita Masakatsu
- <I>Department of Pharmacology</I>
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- Matsuda Atsushi
- <I>Department of Pharmacology</I>
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- Ohori Makoto
- <I>Department of Pharmacology</I>
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- Miyake Hiroshi
- <I>Department of Chemistry, New Drug Research Laboratories, Fujisawa Pharmaceutical Co.. Ltd.</I>
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- Fujii Takashi
- <I>Department of Pharmacology</I>
書誌事項
- タイトル別名
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- Characterization of Dextran Sulfate-Ind
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抄録
We examined the effect of dextran sulfate on guinea pig tracheal vascular permeability. I. v. injection of dextran sulfate (10-100 mg/kg) with captopril (1 mg/kg) induced guinea pig tracheal plasma extravasation. The i. v. administration of bradykinin (0.8-8 μg/kg) with captopril (1 mg/kg) also induced plasma extravasation. Bradykinin B2 antagonists, D-Arg[Hyp3-Thi5-D-Tic7-Tic8]-bradykinin (NPC 16731) and D-Arg[Hyp3-Thi5-D-Tic7-0ic8]-bradykinin (Hoe 140), reduced both dextran sulfate (32 mg/kg)- and bradykinin (2.5 μg/kg)-induced tracheal plasma extravasation in a dose-dependent manner. However, a cyclooxygenase inhibitor, indomethacin (1 mg/kg), and a neurokinin antagonist, {N-[N2-[N-[N-[N-[2, 3-didehydro-N-methyl-N-[N-[3-(2-pentylphenyl)-propionyl]-L-threonyl] tyrosyl-L-Ieucynyl]-D-phenylalanyl]-L-allo-threonyl]-L-asparaginyl]-L-serine-ϒ-lactone} (FK 224) (1 mg/kg), had no effect on tracheal plasma extravasation induced by dextran sulfate and bradykinin. Dextran sulfate (32 mg/kg) with captopril (1 mg/kg) greatly increased the bradykinin level in guinea pig plasma. This evidence suggests that dextran sulfate releases bradykinin in guinea pig plasma and causes guinea pig tracheal plasma extravasation via the activation of bradykinin B2-receptors.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 72 (3), 217-221, 1996
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204286373504
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- NII論文ID
- 10008675926
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK28XntFGjsb4%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 4080031
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- PubMed
- 8957682
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可