Menadione Toxicity in Cultured Rat Cortical Astrocytes

Access this Article

Author(s)

Abstract

We examined the effect of menadione on the morphology and viability of cultured astrocytes. Exposure of astrocytes to menadione induced a progressive cell death. The toxic effect of menadione was concentration- and time-dependent. Menadione toxicity was blocked by antioxidants, superoxide dismutase, catalase and iron chelators, indicating that superoxide anions (0<SUB>2</SUB>¯), hydrogen peroxide (H<SUB>2</SUB>0<SUB>2</SUB>) and hydroxyl radicals (''OH) are all involved in menadione toxicity. Menadione cyiotoxicity should be useful as a model for studying the mechanisms underlying oxidative injury in the brain and for the screening of drugs that may attenuate cell damage caused by oxidative stress.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 72(4), 299-306, 1996-12-01

    The Japanese Pharmacological Society

References:  19

Cited by:  8

Codes

  • NII Article ID (NAID)
    10008676394
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4121848
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
Page Top