Menadione Toxicity in Cultured Rat Cortical Astrocytes.

• Abe Kazuho

  <I>Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo</I>

• Saito Hiroshi

  <I>Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo</I>

書誌事項

タイトル別名

• Menadione Toxicity in Cultured Rat Cort

抄録

We examined the effect of menadione on the morphology and viability of cultured astrocytes. Exposure of astrocytes to menadione induced a progressive cell death. The toxic effect of menadione was concentration- and time-dependent. Menadione toxicity was blocked by antioxidants, superoxide dismutase, catalase and iron chelators, indicating that superoxide anions (0₂¯), hydrogen peroxide (H₂0₂) and hydroxyl radicals (''OH) are all involved in menadione toxicity. Menadione cyiotoxicity should be useful as a model for studying the mechanisms underlying oxidative injury in the brain and for the screening of drugs that may attenuate cell damage caused by oxidative stress.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 72 (4), 299-306, 1996

  公益社団法人 日本薬理学会

キーワード

• Menadione
• Toxicity
• Reactive oxygen species
• Astrocyte
• Culture

詳細情報

• CRID: 1390282679261777920
• NII論文ID: 10008676394
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.72.299
• COI: 1:CAS:528:DyaK2sXisVansw%3D%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• NDL書誌ID: 4121848
• PubMed: 9015738
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4121848
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819338818?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819338818?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1997222019
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
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