Effect of 5,6,7,8 : Tetrahydroneopterin on Oxidative Modification of Low : Density Lipoprotein, and Its Uptake in the Macrophage : Like Cell Line J774

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Author(s)

Abstract

Since oxidative modification of low-density lipoprotein (LDL) and uptake of the oxidized LDL by macrophages are closely related to the pathogenesis of atherosclerosis, we examined the inhibitory effect of 5, 6, 7, 8-tetrahydroneopterin (NPH<SUB>4</SUB>) on Cu(II)-induced lipid peroxidation of LDL. NPH<SUB>4</SUB> significantly inhibited both lipid peroxidation and the associated increase of electrophoretic mobility of ApoB protein. Furthermore, NPH<SUB>4</SUB> suppressed the uptake of oxidized [<SUB>14</SUB>C]oleyl-esterified LDL by the macrophage-like cell line J774. NPH<SUB>4</SUB> may be a candidate for the treatment of atherosclerosis and other active oxygen-related diseases.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 72(4), 375-379, 1996-12-01

    The Japanese Pharmacological Society

References:  18

Codes

  • NII Article ID (NAID)
    10008676651
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00215198
  • NDL Article ID
    4121856
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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