平滑筋における薬物レセプターメカニズム : β-クロロエチルアミン親和性および非親和性レセプターメカニズム Drug Receptor Mechanisms in Smooth Muscle : β-Chloroethylamine-Sensitive and -Resistant Receptor Mechanisms

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Author(s)

    • Koike Katsuo KOIKE Katsuo
    • 東邦薬科大学化学薬理学教室 Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
    • OKAYASU Ayako
    • 東邦薬科大学化学薬理学教室 Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences

Abstract

Both α<SUB>1</SUB>-adrenoceptors and M<SUB>3</SUB>-cholinoceptors can be divided into two subtypes discriminated by the β-chloroethylamines, chloroethylclonidine and propylbenzilylcholine mustard (PrBCM), only in the presence of GTP. The full agonists interact with both subtypes to induce responses. The partial agonists activate one of them to induce responses but behave as competitive antagonists when they interact with the other. The responses mediated through the receptors that are activated by the partial agonists are resistant to myosin light chain kinase inhibitors, while the response through the activation of the other receptors are suppressed by the inhibitors. The receptor stimulations through α<SUB>1A</SUB>-adrenoceptor and PrBCM-sensitive M<SUB>3</SUB>-cholinoceptor subtypes mainly activate the myosin light chain-phosphorylationindependent pathway mediated through protein kinase C and low molecular weight GTP-binding protein, whereas the stimulations through α<SUB>1B</SUB>-adrenoceptors and the PrBCM-phosphorylation-dependent pathway are directly related to Ca<SUP>2+</SUP> calmodulin.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 73(1), 1-22, 1997-01-01

    The Japanese Pharmacological Society

References:  89

Codes

  • NII Article ID (NAID)
    10008676686
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    REV
  • ISSN
    00215198
  • NDL Article ID
    4131790
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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