Dissociation of β-Adrenoceptor Numbers from mRNA Levels during Acute Ischemia in Rat Myocardium

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To explore alterations in messenger RNA (mRNA)for the β-adrenoceptor (β3-AR)in ischemic myocardium, we compared the mRNA levels for, β-AR in ischemic and nonischemic myocardium by <I>in situ</I> hybridization using a radioisotope imaging system. We also compared these mRNA levels in ischemic and nonischemic myocardium with the number of the β-AR by radioligand binding assay. The mRNAs for β-AR were diffusely distributed in normal hearts. The level of mRNA detected by <I>in situ</I> hybridization was reduced by acute ischemia, whereas the number of β-AR was increased. Although the number of β-AR was increased in the myocardium with one or three hours ischemia, the total function in β-AR-stimulatory G protein-adenylate cyclase system was not changed. There is a discrepancy between β-AR mRNA and protein levels in the acute ischemic rat ventricular myocardium.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 73(1), 23-28, 1997-01-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008676776
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4131791
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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