Increase of Cl^- Secretion Induced by Kampo Medicine (Japanese Herbal Medicine), Sai-rei-to, in Mongolian Gerbil Middle Ear Epithelium

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Abstract

<I>Sai-rei-to</I>, a type of Kampo medicine (Japanese herbal medicine), has been shown to be clinically effective in treating patients with otitis media with effusion. The effect of <I>Sai-rei-to</I> on the ion transport of the middle ear surface epithelium cultured from the Mongolian gerbil was investigated by using an Ussing chamber. Application of <I>Sai-rei-to</I> to the mucosal bath but not the serosal bath induced an increase in the short-circuit current (I<SUB>sc</SUB>)in the basal state. The increase in I<SUB>sc</SUB> was almost completely inhibited by addition of diphenylamine-2-carboxylic acid but not by amiloride, indicating enhancement of Cl<SUP>-</SUP> secretion. On the basis of the lack of changes in the intracellular Ca<SUP>2+</SUP> concentration and a sideness of action, the effect of <I>Sai-rei-to</I> on I<SUB>sc</SUB> is thought to be a direct and selective activation on the apical Cl<SUP>-</SUP> channel.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 73(1), 29-32, 1997-01-01

    The Japanese Pharmacological Society

References:  12

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008676796
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4131792
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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