Angiotensin II-Induced Pulmonary Edema in a Rabbit Model

Access this Article

Author(s)

    • Wang Li-man WANG Li-man
    • Department of Preventive Medicine, Division of Social Medicine, Medical Research Institute, Tokyo Medical and Dental University
    • SANAKA Masaki
    • Department of Preventive Medicine, Division of Social Medicine, Medical Research Institute, Tokyo Medical and Dental University
    • KOIKE Yuichi
    • Department of Preventive Medicine, Division of Social Medicine, Medical Research Institute, Tokyo Medical and Dental University
    • MINESITA Satoru
    • Department of Preventive Medicine, Division of Social Medicine, Medical Research Institute, Tokyo Medical and Dental University

Abstract

We conducted the present study to propose a rabbit model of pulmonary edema (PE)induced by angiotensin II (All)and to test the preventive effect of losartan on this form of PE. All was administered to rabbits intravenously at 50, 100, 150 or 300 μg/kg, either by continuous infusion (10 min)or by bolus injection (30 sec). Continuously administered All (150 μg/kg)induced PE in most cases, while a bolus injection of the same dosage did not. Additionally, the incidence of PE increased with higher dosages of All when it was infused continuously. A newly established parameter, the area under the systolic blood pressure-time curve corrected by baseline (cAUC), was prone to rise as the incidence of PE increased. Moreover, cAUC signficantly correlated with the wet-dry lung weight ratio (r=0.66, P<0.05). Subsequently, 0.5 or 3.0 mg/kg of losartan was given before continuous infusion of 150 μg/kg of All. The higher dosage of losartan prevented PE completely, while the lower one did so moderately. We concluded that intravenous administration of All induces PE, probably as a result of increasing afterload. Furthermore, an adequate dosage of losartan can prevent PE because it reduces the pressor effect of All.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 73(1), 33-40, 1997-01-01

    The Japanese Pharmacological Society

References:  22

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008676809
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4131793
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
Page Top