Continuous Infusion of β-Amyloid Protein into the Rat Cerebral Ventricle Induces Learning Impairment and Neuronal and Morphological Degeneration
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- Nitta Atsumi NITTA Atsumi
- Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine
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- Fukuta Taneo FUKUTA Taneo
- Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine
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- Hasegawa Takaaki [他] HASAGAWA Takaaki
- Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine
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- NABESIMA Toshitaka
- Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine
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著者
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- Nitta Atsumi NITTA Atsumi
- Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine
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- Fukuta Taneo FUKUTA Taneo
- Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine
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- Hasegawa Takaaki [他] HASAGAWA Takaaki
- Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine
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- NABESIMA Toshitaka
- Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine
抄録
To investigate the toxicity of β-amyloid protein, a component of the senile plaques in Alzheimer''s disease, it was infused into the cerebral ventricle of rats for 14 days by a mini-osmotic pump. Performances in the water maze and passive avoidance tasks in β-amyloid protein-treated rats were impaired. Choline acetyltransferase activity significantly decreased in the hippocampus both immediately and 2 weeks after the cessation of the infusion. However, the learning impairment was recoverable 2 weeks after cessation of the infusion. Both immediately and 2 weeks after the cessation of the infusion, glial fibrillary acidic protein immunoreactivity increased. Furthermore, β-amyloid protein altered the staining in the nuclei of hippocampal cells for only 2 weeks after the cessation. These results suggest that β-amyloid protein produces some damage in the central nervous system in vivo.
収録刊行物
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- The Japanese journal of pharmacology
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The Japanese journal of pharmacology 73(1), 51-57, 1997-01-01
The Japanese Pharmacological Society
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