Influences of Ovariectomy and Continuous Replacement of 17β-Estradiol on the Tail Skin Temperature and Behavior in the Forced Swimming Test in Rats

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Author(s)

    • Okada Mikiko OKADA Mikiko
    • Drug Discovery Research Unit, Research & Development Subdivision, Pharmaceutical Division, Ciba-Geigy Japan Limited
    • NAKAO Kenzo
    • Drug Discovery Research Unit, Research & Development Subdivision, Pharmaceutical Division, Ciba-Geigy Japan Limited
    • INUKAI Toshiya
    • Drug Discovery Research Unit, Research & Development Subdivision, Pharmaceutical Division, Ciba-Geigy Japan Limited

Abstract

The effect of ovariectomy and continuous subcutaneous replacement of 17β-estradiol was examined in female Wistar rats. Tail skin temperature significantly increased in ovariectomized rats 6 days after ovariectomy, and the elevated level was sustained until 21 days after ovariectomy. 17β-Estradiol at doses of 0.3 and 1.0 μg/body/day suppressed the increases in tail skin temperature. In the forced swimming test, the ovariectomized control rats showed significantly prolonged immobility time in comparison with sham-ovariectomized rats 14 days after ovariectomy. The duration of immobility of ovariectomized rats treated with 17β-estradiol (0.3, 1.0, 3.0 μg/body/day)or maprotiline (0.6 mg/body/day)was significantly shorter than that of ovariectomized control rats.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 73(1), 93-96, 1997-01-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008676988
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4131799
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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