β_1-Adrenoceptor-Mediated Relaxation by Norepinephrine in Dog Hepatic Arteries

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Author(s)

Abstract

Dog hepatic arterial strips treated with prazosin responded to norepinephrine with concentration-related, endothelium-independent relaxations, the maximal response being 81.7% of the papaverineinduced maximal relaxation that was markedly greater than that in renal arteries. The norepinephrineinduced relaxation in hepatic arteries was significantly attenuated by metoprolol but not influenced by butoxamine. Relaxant responses to norepinephrine of dog hepatic arteries appear to be mediated by the β<SUB>1</SUB>-adrenoceptor subtype, like those of coronary arteries. Evidence for functioning of the β<SUB>1</SUB>-subtype in hepatic arteries would contribute to the analysis of neural and hormonal regulation of blood flow in the liver.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 73(1), 101-103, 1997-01-01

    The Japanese Pharmacological Society

References:  10

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008677017
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4131801
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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