β_1-Adrenoceptor-Mediated Relaxation by Norepinephrine in Dog Hepatic Arteries

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Dog hepatic arterial strips treated with prazosin responded to norepinephrine with concentration-related, endothelium-independent relaxations, the maximal response being 81.7% of the papaverineinduced maximal relaxation that was markedly greater than that in renal arteries. The norepinephrineinduced relaxation in hepatic arteries was significantly attenuated by metoprolol but not influenced by butoxamine. Relaxant responses to norepinephrine of dog hepatic arteries appear to be mediated by the β<SUB>1</SUB>-adrenoceptor subtype, like those of coronary arteries. Evidence for functioning of the β<SUB>1</SUB>-subtype in hepatic arteries would contribute to the analysis of neural and hormonal regulation of blood flow in the liver.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 73(1), 101-103, 1997-01-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008677017
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4131801
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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