β1-Adrenoceptor-Mediated Relaxation by Norepinephrine in Dog Hepatic Arteries

• Shiraishi Susumu

  Department of Pharmacology, Shiga University of Medical Sciences

• Okamura Tomio

  Department of Pharmacology, Shiga University of Medical Sciences

• Toda Noboru

  Department of Pharmacology, Shiga University of Medical Sciences

書誌事項

タイトル別名

• .BETA.1-Adrenoceptor-Mediated Relaxation by Norepinephrine in Dog Hepatic Arteries.
• ベータ1 Adrenoceptor-Mediated Relaxation b

抄録

Dog hepatic arterial strips treated with prazosin responded to norepinephrine with concentration-related, endothelium-independent relaxations, the maximal response being 81.7% of the papaverineinduced maximal relaxation that was markedly greater than that in renal arteries. The norepinephrineinduced relaxation in hepatic arteries was significantly attenuated by metoprolol but not influenced by butoxamine. Relaxant responses to norepinephrine of dog hepatic arteries appear to be mediated by the β₁-adrenoceptor subtype, like those of coronary arteries. Evidence for functioning of the β₁-subtype in hepatic arteries would contribute to the analysis of neural and hormonal regulation of blood flow in the liver.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 73 (1), 101-103, 1997

  公益社団法人 日本薬理学会

キーワード

• Hepatic artery
• Norepinephrine
• β<SUB>1</SUB>-Adrenoceptor

詳細情報

• CRID: 1390282679263407232
• NII論文ID: 10008677017
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.73.101
• COI: 1:CAS:528:DyaK2sXnsFGjsA%3D%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• NDL書誌ID: 4131801
• PubMed: 9032140
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4131801
• Web Site: https://search.jamas.or.jp/link/ui/1997125012
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可