Suramin Inhibits Glucose : Induced Ca^<2+> Response in Single Rat Pancreatic β Cells

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Author(s)

Abstract

It is reported that glucose releases ATP with insulin from pancreatic βcells. Nuramin (50-200μM), a purinoceptor blocker, reversibly and dose-dependently inhibited the rise in cytoplasmic calcium concentration ([Ca<SUP>2+</SUP>]<SUB>i</SUB>) induced by glucose and by ATP in single β cells. Suramin did not inhibit the glucose-induced increase in NAD(P)H fluorescence. The rise in [Ca<SUP>2+</SUP>]<SUB>i</SUB> induced by tolbutamide (an inhibitor of ATP-sensitive K<SUP>+</SUP> channels), arginine (a cationic amino acid) and acetylcholine was unaffected by suramin (50-200 μM). This suggests that suramin inhibits the glucose-induced Ca<SUP>2+</SUP> response without an inhibitory effect on glucose metabolism, K<SUP>+</SUP> channels, voltage-dependent Ca<SUP>2+</SUP> influx or Ca<SUP>2+</SUP> release from internal Ca<SUP>2+</SUP> stores and that a purinergic mechanism is involved in the glucose response in β cells.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 73(2), 179-182, 1997-02-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008677286
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4153694
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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