Methamphetamine : Induced Sensitization of Dopamine Release via a Metabotropic Glutamate Receptor Mediated Pathway in Rat Striatal Slices

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Author(s)

Abstract

We studied the roles of metabotropic glutamate receptors in methamphetamine (MAP)induced sensitization of dopamine (DA) release from striatal slices. Rats were first treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days. After a 6-day withdrawal, DA release from striatal slices evoked by ±-1-aminocyclopentane-<I>trans</I>-1, 3-dicarboxylic acid (trans-ACPD)was measured. transACPD-induced DA release was significantly enhanced in MAP-sensitized rats, but the inactive form of trans-ACPD (1R, 3S-ACPD) did not enhance DA release. The active form of trans-ACPD (1S, 3R-ACPD) (0.1 mM) -evoked DA release was attenuated by treatment with 0.4 MM RS-α-methyl-4-carboxyphenylglycine, a metabotropic glutamate receptor antagonist. The present results suggest that metabotropic glutamate receptors play an important role in expression of MAP-induced sensitization.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 73(3), 243-246, 1997-03-01

    The Japanese Pharmacological Society

References:  14

Cited by:  3

Codes

  • NII Article ID (NAID)
    10008677501
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4196919
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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