Methamphetamine-Induced Sensitization of Dopamine Release via a Metabotropic Glutamate Receptor Mediated Pathway in Rat Striatal Slices.
-
- Arai Ikumi
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62
-
- Shimazoe Takao
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62
-
- Shibata Shigenobu
- Department of Pharmacology, School of Human Sciences, Waseda University
-
- Inoue Hirotaka
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62
-
- Yoshimatsu Akiko
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62
-
- Watanabe Shigenori
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62
書誌事項
- タイトル別名
-
- Methamphetamine-Induced Sensitization o
この論文をさがす
抄録
We studied the roles of metabotropic glutamate receptors in methamphetamine (MAP)induced sensitization of dopamine (DA) release from striatal slices. Rats were first treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days. After a 6-day withdrawal, DA release from striatal slices evoked by ±-1-aminocyclopentane-trans-1, 3-dicarboxylic acid (trans-ACPD)was measured. transACPD-induced DA release was significantly enhanced in MAP-sensitized rats, but the inactive form of trans-ACPD (1R, 3S-ACPD) did not enhance DA release. The active form of trans-ACPD (1S, 3R-ACPD) (0.1 mM) -evoked DA release was attenuated by treatment with 0.4 MM RS-α-methyl-4-carboxyphenylglycine, a metabotropic glutamate receptor antagonist. The present results suggest that metabotropic glutamate receptors play an important role in expression of MAP-induced sensitization.
収録刊行物
-
- Jpn.J.Pharmacol.
-
Jpn.J.Pharmacol. 73 (3), 243-246, 1997
公益社団法人 日本薬理学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204287836672
-
- NII論文ID
- 10008677501
-
- NII書誌ID
- AA00691188
-
- COI
- 1:CAS:528:DyaK2sXitFKqt7c%3D
-
- ISSN
- 13473506
- 00215198
-
- NDL書誌ID
- 4196919
-
- PubMed
- 9127819
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可