Persistence of Cyclopiazonic Acid : Induced Endothelium : Dependent Vasodilatation in Spontaneously Hypertensive and Streptozotocin : Induced Diabetic Rats

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Author(s)

Abstract

We recently reported that cyclopiazonic acid (CPA)r eleases a novel endothelium-derived relaxing factor that is not prostacyclin, nitric oxide or endothelium-derived hyperpolarizing factor in rat mesenteric arterial bed. The acetylcholine-induced vasodilatation of the isolated mesenteric bed in spontaneously hypertensive rats (SHR) was not different from that in Wistar Kyoto rats (WKY), but it was significantly smaller in streptozotocin (STZ) -induced diabetic rats than in age-matched controls. The CPAinduced vasodilatation was not affected in SHR or in STZ-induced diabetic rats. These results suggest that the CPA-induced endothelium-dependent vasodilatation is resistant to the effects of diabetes.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 73(3), 247-250, 1997-03-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008677516
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4196920
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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