Biphasic Effects of D_3 : Receptor Agonists, 7 : OH : DPAT and PD128907, on the D_1 : Receptor Agonist : Induced Hyperactivity in Mice

この論文にアクセスする

この論文をさがす

著者

抄録

Effects of D<SUB>3</SUB>-receptor agonists, 7-OH-DPAT and PD128907, on the D<SUB>1</SUB>-receptor agonist SKF81297-induced hyperactivity in mice were examined. 7-OH-DPAT and PD128907 significantly suppressed the SKF81297-induced hyperactivity at low doses, but significantly potentiated the hyperactivity at high doses. These D<SUB>3</SUB>-agonists alone had no effect on the motor activity. A κ-receptor agonist that reduces dopamine release had no effect on the SKF81297-induced hyperactivity. These results suggest that lower doses of 7-OH-DPAT and PD128907 may negatively influence the D<SUB>1</SUB>-receptor mediated behaviors via post synaptic D<SUB>3</SUB>-receptors. On the other hand, higher doses of these compounds may positively influence these behaviors via D<SUB>2</SUB> or D<SUB>3</SUB>-receptors.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 73(3), 251-254, 1997-03-01

    公益社団法人 日本薬理学会

参考文献:  15件中 1-15件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008677532
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4196921
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ