Calcitonin Gene : Related Peptide Inhibits Nonadrenergic Noncholinergic Contraction of Guinea Pig Distal Colon
In the guinea pig distal colon, calcitonin gene-related peptide (CGRP, 0.1 30 nM) produced a concentration-dependent inhibition in electrically-evoked nonadrenergic noncholinergic (NANC)contractions and exogenous substance P-induced contractions. Both the inhibitory actions of CGRP were insensitive to human CGRP(8-37) (1-3 μM), a CGRP<SUB>1</SUB> receptor antagonist. These results indicate that in the distal colon, CGRP inhibits electrically-evoked NANC contraction through a postjunctional mechanism, in contrast to our previously described results that CGRP enhances the NANC contraction of guinea pig proximal colon via a prejunctinal mechanism.
- The Japanese journal of pharmacology
The Japanese journal of pharmacology 73(3), 255-257, 1997-03-01