Calcitonin Gene : Related Peptide Inhibits Nonadrenergic Noncholinergic Contraction of Guinea Pig Distal Colon

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Author(s)

Abstract

In the guinea pig distal colon, calcitonin gene-related peptide (CGRP, 0.1 30 nM) produced a concentration-dependent inhibition in electrically-evoked nonadrenergic noncholinergic (NANC)contractions and exogenous substance P-induced contractions. Both the inhibitory actions of CGRP were insensitive to human CGRP(8-37) (1-3 μM), a CGRP<SUB>1</SUB> receptor antagonist. These results indicate that in the distal colon, CGRP inhibits electrically-evoked NANC contraction through a postjunctional mechanism, in contrast to our previously described results that CGRP enhances the NANC contraction of guinea pig proximal colon via a prejunctinal mechanism.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 73(3), 255-257, 1997-03-01

    The Japanese Pharmacological Society

References:  5

Codes

  • NII Article ID (NAID)
    10008677548
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4196922
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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