Calcitonin Gene-Related Peptide Inhibits Nonadrenergic Noncholinergic Contraction of Guinea Pig Distal Colon.

• Kojima Shu-ichi

  Department of Pharmacology, Dokkyo University School of Medicine

Bibliographic Information

Other Title

• Calcitonin Gene-Related Peptide Inhibit

Abstract

In the guinea pig distal colon, calcitonin gene-related peptide (CGRP, 0.1 30 nM) produced a concentration-dependent inhibition in electrically-evoked nonadrenergic noncholinergic (NANC)contractions and exogenous substance P-induced contractions. Both the inhibitory actions of CGRP were insensitive to human CGRP(8-37) (1-3 μM), a CGRP₁ receptor antagonist. These results indicate that in the distal colon, CGRP inhibits electrically-evoked NANC contraction through a postjunctional mechanism, in contrast to our previously described results that CGRP enhances the NANC contraction of guinea pig proximal colon via a prejunctinal mechanism.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 73 (3), 255-257, 1997

  The Japanese Pharmacological Society

Keywords

• Calcitonin gene-related peptide (CGRP)
• Nonadrenergic noncholinergic (NANC)transmission
• Colon (guinea pig)

Details

• CRID: 1390001204287874432
• NII Article ID: 10008677548
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.73.255
• COI: 1:CAS:528:DyaK2sXitFKqtLw%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL BIB ID: 4196922
• PubMed: 9127822
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4196922
• Web Site: https://search.jamas.or.jp/link/ui/1997144832
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed