Inhibition by Adrenomedullin of the Adrenergic Neurogenic Response in Canine Mesenteric Arteries

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Author(s)

Abstract

Adrenomedullin (AM)inhibited the pressor action caused by transmural electrical stimulation in perfused isolated canine mesenteric arteries. The inhibitory potency of AM was greater than that of calcitonin gene-related peptide (CGRP) or proadrenomedullin NH<SUB>2</SUB>-terminal 20 peptide (PAMP). [8-37]CGRP did not affect the inhibitory action of AM, but suppressed the CGRP-induced inhibition. It may be concluded that AM has an ability to inhibit adrenergic neuronal transmission without the mediation of CGRP<SUB>1</SUB> receptors in the peripheral vasculature, and this inhibition partly participates in the potent hypotensive action of AM.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 73(3), 259-261, 1997-03-01

    The Japanese Pharmacological Society

References:  10

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008677554
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4196923
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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