Effect of Japanese Angelica Root Extract on Pentobarbital-Induced Sleep in Group-Housed and Socially Isolated Mice:Evidence for the Central Action

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Author(s)

Abstract

We investigated the effect of the aqueous extract of Japanese angelica root (JAR)on pentobarbital (PB)sleep in group-housed and socially isolated mice. The JAR extract (1.25-2.5 g/kg, p.o.)dose-dependently reversed the decrease in PB sleep caused by isolation stress without affecting PB sleep in group-housed mice. The JAR extract (2.5 g/kg, p.o.)also antagonized the decrease in PB sleep caused by the α<SUB>2</SUB>-adrenoceptor antagonists yohimbine and idazoxan (1 mg/kg, i.p.)and the α<SUB>1</SUB>-adrenoceptor agonist methoxamine (200 nmol, i.c.v.)in group-housed mice. These results suggest that the JAR extract reverses changes in the arousal level caused by isolation stress and the activation of central noradrenergic systems.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 73(4), 353-356, 1997-04-01

    The Japanese Pharmacological Society

References:  15

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008677909
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4196933
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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