Cardioprotecvtive Effect of K-7259,a Novel Dlazep Derivative,against Ischemia-Reperfusion Damage in Isolated,Working Rat Hearts

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Author(s)

Abstract

Global ischemia (15 min)followed by reperfusion (10, 20 or 30 min)was performed in isolated, working rat hearts. Ischemia depressed mechanical function, which was not restored by reperfusion of 20 min. Preischemic administration of K-7259 (<I>N, N''</I>-bis[4-(3, 4, 5-trimethoxyphenyl)butyl]homopiperazine dihydrochloride)(1, 5 or 10 μM)decreased the function before ischemia, but it attenuated the ischemia-induced dysfunction during reperfusion (20 min). Postischemic administration of K-7259 (10 μM)or dilazep (20 μM)also attenuated the ischemia-induced dysfunction during reperfusion (30 min). Ischemia-reperfusion (10 min)increased the tissue malondialdehyde level, and postischemic administration of K-7259 (10 μM)or dilazep (20 μM)attenuated the malondialdehyde accumulation. K-7259 has a cardioprotective effect when given either before or after ischemia.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 73(4), 365-369, 1997-04-01

    The Japanese Pharmacological Society

References:  15

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008677957
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4196936
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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