Cardioprotective Effect of K-7259, a Novel Dilazep Derivative, against Ischemia-Reperfusion Damage in Isolated, Working Rat Hearts.

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  • Hoque A.N. Ehsanul
    Department of Pharmacology, Asahikawa Medical College Department of Pharmacology and Toxicology, Medical Sciences Building, University of Western Ontario
  • Hoque Nina
    Department of Pharmacology, Asahikawa Medical College Department of Pharmacology and Toxicology, Medical Sciences Building, University of Western Ontario
  • Hara Akiyoshi
    Department of Pharmacology, Asahikawa Medical College
  • Hashizume Hiroko
    Department of Pharmacology, Asahikawa Medical College
  • Ichihara Kazuo
    Department of Pharmacology, Hokkaido College of Pharmacy
  • Abiko Yasushi
    Department of Pharmacology, Asahikawa Medical College

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タイトル別名
  • Cardioprotective Effect of K-7259 a Nov

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Global ischemia (15 min)followed by reperfusion (10, 20 or 30 min)was performed in isolated, working rat hearts. Ischemia depressed mechanical function, which was not restored by reperfusion of 20 min. Preischemic administration of K-7259 (N, N''-bis[4-(3, 4, 5-trimethoxyphenyl)butyl]homopiperazine dihydrochloride)(1, 5 or 10 μM)decreased the function before ischemia, but it attenuated the ischemia-induced dysfunction during reperfusion (20 min). Postischemic administration of K-7259 (10 μM)or dilazep (20 μM)also attenuated the ischemia-induced dysfunction during reperfusion (30 min). Ischemia-reperfusion (10 min)increased the tissue malondialdehyde level, and postischemic administration of K-7259 (10 μM)or dilazep (20 μM)attenuated the malondialdehyde accumulation. K-7259 has a cardioprotective effect when given either before or after ischemia.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 73 (4), 365-369, 1997

    公益社団法人 日本薬理学会

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